What is CAD analysis?

Besides surfactant characterization, CAD analysis finds application for excipient quantification in general. We provide all our analytical services with the highest quality standards. Each project is carried out by experienced scientists and every report or data presentation is comprehensively checked by a scientific reviewer.

What is liquid chromatography with charged aerosol detection (LC-CAD)?

Liquid chromatography with charged aerosol detection (LC-CAD) analysis is a powerful technique used for polysorbate quantification and profiling. After a separation step via high-performance liquid chromatography (HPLC), the column eluent is nebulized by a nitrogen flow, the mobile phase is evaporated together with other volatile components.

How does HPLC CAD work?

Detection: charged aerosol particles transfer to a collector, where an extremely sensitive electrometer measures the aggregate charge. This process generates a signal directly proportional to the mass of the analyte present. Discover how the CAD can benefit your HPLC analysis. Learn best lab practices for setting up your HPLC-CAD system.

What is the difference between CAD and eLSD?

The CAD response depends on particle charge, and the detector can measure smaller charged particles and detect less analyte, which equals better sensitivity. In contrast, the ELSD response depends on particle size, and the efficiency of light scattering greatly decreases as the particle size and amount of analyte decrease.